The Most Fatal 2014 Outbreak of Ebolavirus Disease in Western Africa

Mohajan, Haradhan (2014): The Most Fatal 2014 Outbreak of Ebolavirus Disease in Western Africa. Published in: American Journal of Epidemiology and Infectious Disease , Vol. 2, No. 4 (28 September 2014): pp. 101-108.

Abstract

The first Ebolavirus diseases outbreak was in Zaire (now Democratic Republic of the Congo) in 1976. The 2014 Ebola outbreak is the deadliest and the largest Ebola outbreak in history and the first in western Africa. More than 2,746 people had died from this outbreak. The disease is a severe, often fatal in humans and nonhuman primates. It cannot naturally transmit through the air, water or food and can be spread by direct contact with blood and secretions of the infected patients. At present there is no standard treatment for Ebolavirus diseases; only supportive therapy is available. Hence prevention is the best way by not traveling to areas where the virus is found. The paper represents an elementary idea of Ebolavirus diseases to create consciousness of the disease among common people.

• Item Type: MPRA Paper
• Language: English
• Keywords: Ebolavirus, Africa, WHO, CDC
• Subjects: I - Health, Education, and Welfare > I1 - Health > I14 - Health and Inequality

References

[1] Baron, R.C., McCormick, J.B. and Zubeir, O.A., “Ebola Virus Disease in Southern Sudan: Hospital Dissemination and Intrafamilial Spread”, Bulletin of the World Health Organization, .1983. 61(6): 997–1003.

[2] BBC News, “Nigeria ‘on Red Alert’ Over Ebola Death in Lagos, BBC News”, 26 July 2014.

[3] Becker, S., Rinne, C., Hofsass, U., Klenk, H.D. and Muhlberger, E. “Interactions of Marburg Virus Nucleocapsid Proteins”, Virology, 1998. 249 (2), 406–417.

[4] Beniac, D.R., Melito P,L., deVarennes, S.L., Hiebert, S.L., Rabb, M.J., Lamboo, L.L., Jones, S.M., and Booth, T.F., “The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy”, PLoS One, 2012. 7(1), e29608.

[5] Bharat, T.A.M., Noda, T., Riches, J.D., Kraehling, V., Kolesnikova, L., Becker, S., Kawaoka, Y., and Briggs, J.A.G., “Structural Gissection of Ebola Virus and its Assembly Determinants Using Cryoelectron Tomography”, PNAS, USA, 2012. 109 (11): 4275–4280.

[6] Bowen, E.T., Lloyd, G., Harris, W.J., Platt, G.S., Baskerville, A. and Vella, E.E., “Viral Haemorrhagic Fever in Southern Sudan and Northern Zaire”, Preliminary Studies on the Aetiological Agent, Lancet, 1977. i: 571–573.

[7] CDC, “Known Cases and Outbreaks of Ebola Hemorrhagic Fever”, Center for Disease Control and Prevention, US Department of Health and Human Services. 2008.

[8] CDC, “Ebola Hemorrhagic Fever Information Packet”, Centers for Disease Control and Prevention, US Department of Health and Human Services. 2009.

[9] CDC, “CDC Urges all US Residents to Avoid None-essential Travel to Liberia, Guinea and Sierra Leon Because of an Unprecedented Outbreak of Ebola”, CDC, July 31, 2014. 2014a.

[10] CDC, “Ebola Hemorrhagic Fever”, US Department of Health and Human Services. 2014b.

[11] CDC, “Update: 22 August 2014, Ebola Hemorrhagic Fever”, Center for Disease Control and Prevention. US Department of Health and Human Services. 2014c.

[12] CDC, “2014 Ebola Outbreak in West Africa, Update: 17 September 2014”, Centers for Disease Control and Prevention, US Department of Health and Human Services. 2014d.

[13] Chepurnov, A.A., Chuev, P., P’Iankov, O.V., Efimova, I.V., “The Effect of Some Physical and Chemical Factors on Inactivation of the Ebola Virus”, Voprosy Virusologii. 1995, 40(2):74–76.

[14] Colebunders, R. and Borchert M., “Ebola Haemorrhagic Fever: A Review”, Journal of Infection, 2000. 40: 16–20.

[15] ECDC, “Outbreak of Ebola Virus Disease in West Africa, European Centre for Disease Prevention and Control”, Third update, 1 August 2014. Stockholm: ECDC; 2014.

[16] Feldmann, H.K., “Molecular Biology and Evolution of Filoviruses”, Archives of Virology Supplementum, 1993. 7: 81–100.

[17] Feldmann, H.K. and Geisbert, T.W. “Ebola Haemorrhagic Fever”, The Lancet, 377(9768): 849–862. 2011.

[18] GoG, “Planned Response to the Ebolavirus Disease Epidemic in Guinea, Ministry of Health Republic of Guinea”, July–December 2014. 2014.

[19] GoL, “Liberia Operational Plan for Accelerated Response to Re-occurrence of Ebola Epidemic”, Ministry of Health and Social Welfare, July–December 2014. 2014.

[20] GoSL, “Sierra Leone Accelerated Ebolavirus Disease Outbreak Response”, Government of Sierra Leone, Ministry of Health and Sanitation, July–December 2014. 2014.

[21] IPAC Guidance, “Infection Prevention and Control Guidance for Patients with Suspected or Confirmed Ebola Virus Disease (EVD) in Ontario Health Care Settings”, Public Health Ontario. 2014.

[22] Jahrling, P.B., Geisbert, T.W., Dalgard, D.W., Johnson, E.D., Hall, W.C. and Peters, C.J. “Preliminary Report: Isolation of Ebola Virus from Monkeys Imported to USA”. Lancet, 335(8688): 502–505. 1990.

[23] Klenk, H.D. and Feldmann, H., “Ebola and Marburg Viruses: Molecular Cellular Biology”, British Library Cataloguing-in-Publication Data, Garland Science, Horizon Bioscience, Wymondhan UK. 2004.

[24] Kuhn, J.H., Becker, S., Ebihara, H., Geisbert, T.W., Johnson, K.M., Kawaoka, Y., Lipkin, W.I., Negredo, A.I., Nichol, S.T., Peters, C.J., Tenorio, A., Volchkov, V.E. and Jahrling, P.B., “Proposal for a Revised Taxonomy of the Family Filoviridae: Classification, Names of Taxa and Viruses, and Virus Abbreviations”, Archives of Virology, 155(12): 2083–2103. 2010.

[25] MacNeil, A., Farnon, E.C., Morgan, O.W., Gould, P., Boehmer, T.K., Blaney, D.D., Wiersma, P., Tappero, J.W., Nichol, S.T., Ksiazek, T.G., and Rollin, P.E., “Filovirus Outbreak Detection and Surveillance: Lessons From Bundibugyo”, The Journal of Infectious Diseases, 204:S761–S767. 2011.

[26] Mark, M., “Ebola Outbreak: Nurse who Treated First Victim in Nigeria Dies”, The Guardian, 7 August 2014. 2014.

[27] Mateo, M., Carbonnelle, C., Martinez, M.J., Reynard, O., Page, A., Volchkova, V.A. and Volchov, V.E., “Knockdown of Ebola Virus VP24 Impairs Viral Nucleocapsid Assembly and Prevents Virus Replication”, The Journal of Infectious Diseases, 204 Suppl 3, S892–S896. 2011.

[28] Muhlberger, E., Lotfering, B., Klenk, H.D. and Becker, S., “Three of the Four Nucleocapsid Proteins of Marburg Virus, NP, VP35, and L, are Sufficient to Mediate Replication and Transcription of Marburg Virus-specific Monocistronic Minigenomes”, Journal of Virology, 72(11): 8756–8764. 1998.

[29] Muhlberger, E., Weik, M., Volchkov, V.E., Klenk, H.D. and Becker, S., “Comparison of the Transcription and Replication Strategies of Marburg Virus and Ebola Virus by Using Artificial Replication Systems”, Journal of Virology, 73(3): 2333–2342.1999.

[30] Nanbo, A., Watanabe, S., Halfmann, P. and Kawaoka, Y., “The Spatio-temporal Distribution Dynamics of Ebola Virus Proteins and RNA in Infected Cells”, Nature, Scientific Report, srep 01206. 2013.

[31] Public Health Agency of Canada, “Ebola Virus, Pathogen Safety Data Sheet–Infectious Substances”, Ottawa: Public Health Agency of Canada. 2010.

[32] Reuters, “Lagos Records Second Ebola Case in Doctor Who Treated Victim: Nigeria Health Minister”, 4 August 2014. 2014.

[33] Rollin, P.E., Williams, R.J., Bressler, D.S., Pearson, S., Cottingham, M., Pucak, G., Sanchez, A., Trapper, S.G., Peters, R.L., Greer, P.W., Zaki, S., Demarcus, T., Hendricks, K., Kelly, M., Simpson, D., Geisbert, T.W., Jahrling. P.B., Peters, C.J., and Kssiazek, T.G., “Ebola (subtype Reston) Virus among Quarantined Nonhuman Primates Recently Imported from the Philippines to the United States”, The Journal of Infectious Diseases, 179(suppl 1): S108–S114. 1999.

[34] Sanchez, A., Trappier, S.G., Mahy, B.W.J., Peters, C.J. and Nichol, S.T., “The Virion Glycoproteins of Ebolaviruses are Encoded in Two Reading Frames and are Expressed through Transcriptional Editing”, Proceedings of the National Academy of Sciences (PNAS), USA 93: 3602–3607. 1996.

[35] Sanchez, A., Yang, Z., Xu, L., Nabel, G.J., Crews, T. and Peters, C.J. “Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebolavirus”, Journal of Virology, 72: 6442–6447. 1998.

[36] Sullivan, N., Yang, Z.Y. and Nabel, G.J., “Ebola Virus Pathogenesis: Implications for Vaccines and Therapies”, Journal of Virology, 77(18): 9733–9737. 2003.

[37] Volchkov, V.E., Becker, S., Volchkova, V.A., Ternovoj, V.A., Kotov, A.N., Netesov, S.V. and Klenk, H.D. “GP mRNA of Ebolavirus is Edited by the Ebolavirus Polymerase and by T7 and Vaccinia Virus Polymerases”, Virology, 214: 421–430. 1995.

[38] Watanabe, S., Takada, A., Watanabe, T., Ito, H., Kida, H. and Kawaoka, Y., “Functional Importance of the Coiled-coil of the Ebolavirus Glycoprotein”, Journal of Virology, 74: 10194–10201. 2000.

[39] Waterman, T., “Ebola Cote D’Ivoire Outbreaks”, Stanford University. 1999.

[40] WHO, “Ebola Hemorrhagic Fever in Sudan, 1976, Report of a WHO/International Study Team”, Bulletin of the World Health Organization, 56(2): 247–270. 1978a.

[41] WHO, “Ebola Hemorrhagic Fever in Zaire, 1976, Report of an International Commission”, Bulletin of the World Health Organization, 56(2): 271–293. 1978b.

[42] WHO, “End of Ebola Outbreak in Uganda (Press Release)”, World Health Organization, 20 February 2008. 2008a.

[43] WHO, “Interim Infection Control Recommendations for Care of Patients with Suspected or Confirmed Filovirus (Ebola, Marburg) Hemorrhagic Fever”, DP/EPR/WHO, Geneva March 2008. 2008b.

[44] WHO, “Ebola Virus Disease Fact Sheet No. 103”, World Health Organization, March 2014. 2014a.

[45] WHO, “WHO Strategic Action Plan for Ebola Outbreak Response”, July–December 2014. 2014b.

[46] WHO, “WHO Statement on the Meeting of the International Health Regulations Emergency Committee Regarding the 2014 Ebola Outbreak in West Africa”, WHO Statement, 8 August 2014. 2014c.

[47] WHO, “Frequently Asked Questions on Ebola Virus Disease”, Updated 8 July 2014. 2014d.

[48] WHO, “Ebola Virus Disease in Guinea–23 March 2014”, Geneva: WHO; 2014. 2014e.

[49] WHO, “Ebola Virus Disease, West Africa–Update 28 August 2014”, Epidemic & Pandemic Alert and Response (EPR)–Outbreak News (WHO). 2014f.

[50] WHO, “Ebola Death Toll Passes 1,900, Says WHO”, BBC News 17 September 2014. 2014g.

[51] Wikipedia (20140, The Free Encyclopedia, 2014 West Africa Ebola Virus Outbreak.