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The Timing and Probability of Switching to Second-line Regimen - An application to Second-Line Antiretroviral Therapy in India.

Felipa, de Mello-Sampayo (2014): The Timing and Probability of Switching to Second-line Regimen - An application to Second-Line Antiretroviral Therapy in India.

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Abstract

Health fluctuations render the outcome of any treatment switch uncertain, so that decision makers might have to wait for more information before optimally switching treatments. This paper sets up a stochastic model that provides an optimal rule for the timing of treatment switch. The results of the model were then tested empirically with patient-based data on first-line and second-line antiretroviral treatment in India. The empirical results support the findings of the analytical model.

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