Prevalence of neuro-musculoskeletal complications in patients with T2DM

Saif, Mehvish and Ali, Syed Zain and Zehra, Syeda Zufiesha and Zehra, Beenish (2017): Prevalence of neuro-musculoskeletal complications in patients with T2DM. Published in: Advances in Life Science and Technology , Vol. 56, (31 May 2017): pp. 1-12.

Abstract

Diabetes mellitus affects normal metabolizing body function and causes long term organs dysfunctions like blindness, kidney failure, neuropathy and autonomic dysfunction. The musculoskeletal is also affected by T2DM and causes pain, dysfunctions, and disabilities. Thus, this study is to find the prevalence of neuro-musculoskeletal complications in patients with T2DM. This cross sectional survey was conducted in various public and private sector hospitals of four major cities of Pakistan (Islamabad, Karachi, Lahore, and Sargodha) from 1st May to 31st December 2015. The patients of type II diabetes mellitus with both gender and age above 40 were included, and patients with active systemic disease of bones and soft tissues were excluded. A self-structured questionnaire was developed, reviewed by experts, and finalized after calculating their recommendations. The questionnaire was distributed among 600 patients, out of whom 500 patients responded. The non-probability convenient sampling technique was used for data collection. The data was analyzed by SPSS and percentages were calculated to estimate the neuro-musculoskeletal complications in patients with T2DM. The prevalence of neuro-musculoskeletal complication in type II Diabetes mellitus was 100 %, while the frozen shoulder, tingling sensations and ants crawling sensations (61%) were equally the most common neuro-musculoskeletal complications followed by knee pain (53%), low back pain (43%).The most involved age group was 61 to 65 years and 58% patients were with positive family history. The most commonly used way of treatment was medications (90%) and physical therapy (10%). It was proved in study that frozen shoulder, altered sensations, knee pain and back pain have high association with long duration of T2DM.There is association between long duration of diabetes mellitus and neuro-musculoskeletal complications. It is concluded that the prevalence of neuro-musculoskeletal complications is high among patients of T2DM and commonly affects shoulder, back, knee and altered sensation in legs. These are most commonly managed with medications followed by physical therapy.

• Item Type: MPRA Paper
• Language: English
• Keywords: T2DM, neuro-musculoskeletal, complications, frozen shoulder, Range of motion
• Subjects: I - Health, Education, and Welfare > I1 - Health; I - Health, Education, and Welfare > I1 - Health > I10 - General; I - Health, Education, and Welfare > I1 - Health > I11 - Analysis of Health Care Markets; I - Health, Education, and Welfare > I1 - Health > I12 - Health Behavior; I - Health, Education, and Welfare > I1 - Health > I18 - Government Policy ; Regulation ; Public Health; I - Health, Education, and Welfare > I1 - Health > I19 - Other

References

Alonso-Morán, E., Orueta, J.F., Esteban, J.I., Axpe, J.M., González, M.L., Polanco, N.T., Loiola, P.E., Gaztambide, S., & Nuño-Solinís, R. (2015). Multimorbidity in people with type 2 diabetes in the Basque Country (Spain): Prevalence, comorbidity clusters and comparison with other chronic patients. European journal of internal medicine, 26(3), 197-202.

American Diabetes Association, (2013). Economic costs of diabetes in the US in 2012. Diabetes Care 2013, 36(6), 1797.

Angelo, R., de Castro Pochini, A., Andreoli, C.V., Ejnisman, B. (2015). Frozen Shoulder: Etiology (Idiopathic). Shoulder Stiffness: Springer, 33-44.

Andersson, H. I. (2004). The course of non-malignant chronic pain: a 12- year follow-up of a cohort from the general population. European Journal of Pain, 8:47-53.

Ansari, R.M., Dixon, J.B., & Coles, J. (2015). Type 2 Diabetes: Challenges to Health Care System of Pakistan. International Journal of Diabetes Research, 4(1), 7-12.

Baba, M., Davis, W.A., Norman, P.E., & Davis, T.M. (2015). Temporal changes in the prevalence and associates of foot ulceration in type 2 diabetes: The Fremantle Diabetes Study. Journal of diabetes and its complications, 29(3), 356-361.

Arkkila, P., & Gautier, J.F. (2003). Musculoskeletal disorders in diabetes mellitus: an update. Best Practice Research Clinical Rheumatol. 17(6):945-970.

Balk, E.M., Earley, A., Raman, G., Avendano, E.A., Pittas, A.G., & Remington, P.L. (2015). Combined diet and physical activity promotion programs to prevent type 2 diabetes among persons at increased risk: a systematic review for the Community Preventive Services Task Force. Annals of internal medicine, 163(6), 437-451.

Burner, T., & Rosenthal, A. K. (2009). Diabetes and rheumatic diseases. Curr Opin Rheumatol, 21(1):50-54.

Cagliero, E., Apruzzese, W., Perlmutter, G.S., & Nathan, D. M. (2002). Musculoskeletal disorders of the hand and shoulder in patients with diabetes mellitus. American Journal of Med, 112:487.

Canbulat N., Eren, I., Atalar, A.C., Demirhan, M., Eren, S.M., & Ucak, A. (2015). Nonoperative treatment of frozen shoulder: oral glucocorticoids. International orthopaedics, 39(2), 249-254.

Cederberg, H., Stančáková, A., Kuusisto, J., Laakso, M., & Smith, U. (2015). Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?.Journal of internal medicine, 277(5), 540-551.

Engin, F. (2016). ER stress and development of type 1 diabetes. Journal of Investigative Medicine, 64(1), 2-6.

Eymard, F., Parsons, C., Edwards, M.H., Petit-Dop, F., Reginster, J.Y., Bruyère, O., Richette, P., Cooper, C., & Chevalier, X. (2015). Diabetes is a risk factor for knee osteoarthritis progression. Osteoarthritis and Cartilage, 23(6), 851-859.

Fatemi, A., Iraj, B., Barzanian, J., Maracy, M., & Smiley, A. (2015). Musculoskeletal manifestations in diabetic versus prediabetic patients. International journal of rheumatic diseases, 18(7),791-799.

Gautam, D., & Gautam, D. (2014). A Short Review On Anti-Diabetic Agent. PharmaTutor, 2(10), 89-105.

Grey A., & Dalbeth, N. (2003). Bone and rheumatic disorders in diabetes. 48:749.

Haque, A.U., & Aston, J. (2016). A Relationship between Occupational Stress and Organisational Commitment of I.T Sector's Employees in Contrasting Economies. Polish Journal of Management Studies, 14(1), 95-105.

Haque, A. U., and Aston, J. (2016). A Relationship between Occupational Stress and Organizational Commitment of I.T Sector's Employees in Contrasting Economies. Polish Journal of Management Studies. Vol. 14 (1), 95-105.

Haque, A.U., Aston, J., & Kozlovski, E., (2016). Do causes and consequences of stress affect genders differently at operational level? Comparison of the IT sectors in the UK and Pakistan. International Journal of Applied Business, 1(1), 1-7.

Haque, A.U., & Yamoah, F. (2014). Gender Employment Longevity: I.T Staff Response to Organizational Support in Pakistan, International Journal of Academic Research in Business and Social Sciences, 4 (12), 324-347.

Haslock, I. (1914). Common periarticular syndromes. Medical International, 7:173-176.

Hussain, S., Hussain, W., & Hussain, J. (2015). Therapeutic Evaluation of Diabetes Miletus and Their Complications in District Abbottabad Khyber Pakhtunkhwa Pakistan. Journal of Medical, Biological & Pharmaceutical Sciences, 1(1).

Idowu, O.A., Adeniyi, A.F., Babatunde, O.A., Atijosan, O.J., Ogwumike, O.O., & Fawole, H.O. (2015). Prevalence of Self-Reported Low Back Pain among Patients with Type 2 Diabetes Mellitus: A Preliminary Survey. East African Orthopaedic Journal, 9(1), 6-11.

Kapoor A., & Sibbitt Jr. W.L. (1989). Contractures in diabetes mellitus: The syndrome of limited joint mobility. Semin Arthritis Rheum,18:168.

Kelly, S.J., & Ismail, M. (2015). Stress and Type 2 Diabetes: A Review of How Stress Contributes to the Development of Type 2 Diabetes. Annual review of public health, 36, 441-62.

Kiss, C., Szilágyi, M, Paksy, A., & Poór G. (2002). Risk factors for diffuse idiopathic skeletal hyperostosis: a casecontrol study. Rheumatology, 41:27-30.

Lee, C.C., Perkins, B.A., Kayaniyil, S., Harris, S.B., Retnakaran, R., Gerstein, H.C., Zinman, B., & Hanley, A.J. (2015). Peripheral Neuropathy and Nerve Dysfunction in Individuals at High Risk for Type 2 Diabetes: The PROMISE Cohort. Diabetes care. 38(5), 793-800.

Li, B., Lang, N., & Cheng, Z.F. (2015). Serum Levels of Brain-Derived Neurotrophic Factor Are Associated with Diabetes Risk, Complications, and Obesity: a Cohort Study from Chinese Patients with Type 2 Diabetes. Molecular neurobiology, 1-8.

Liu, Z., Fu, C., Wang, W., & Xu, B. (2010). Research prevalence of chronic complications of type 2 diabetes mellitus in outpatients–a cross-sectional hospital based survey in urban China. Health Qual Life Outcomes, 8, 62.

Pai, L.W., Hung, C.T., Li, S.F., Chen, L.L., Chung, Y.C., & Liu, H.L. (2015). Musculoskeletal pain in people with and without type 2 diabetes in Taiwan: a population-based, retrospective cohort study. BMC musculoskeletal disorders, 16(1), 1.

Pai, L.W., Hung, C.T., Li, S.F., Chen, L.L., Chung, Y.C., & Liu, H.L. (2015). Musculoskeletal pain in people with and without type 2 diabetes in Taiwan: a population-based, retrospective cohort study. BMC musculoskeletal disorders, 16(1), 1.

Petri, K.C., Jacobsen, L.V., & Klein, D.J. (2015). Comparable Liraglutide Pharmacokinetics in Pediatric and Adult Populations with Type 2 Diabetes: A Population Pharmacokinetic Analysis. Clinical pharmacokinetics, 54(6), 663-670.

Purohit, S., Sharma, A., & She, J.X. (2015). Luminex and Other Multiplex High Throughput Technologies for the Identification of, and Host Response to, Environmental Triggers of Type 1 Diabetes. BioMed research international.

Moore, C.W., Allen, M.D., Kimpinski, K., Doherty, T.J., & Rice, C.L. (2015). Reduced skeletal muscle quantity and quality in patients with diabetic polyneuropathy assessed by magnetic resonance imaging. Muscle & nerve.

Mortada, M., Ashour, M.M., Abbas, S.F., Ammar, H.A., Ezzeldin, N., Salama, N.A. (2015). FRI0546 Multiple Versus Single Ultrasound Guided Suprascapular Nerve Block in Treatment of Frozen Shoulder in Diabetic Patients. Annals of the Rheumatic Diseases, 74(Suppl 2), 625-625.

Magnusson, K., Hagen, K.B., Østerås, N., Nordsletten, L., Natvig, B., & Haugen, I.K. (2015). Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population‐Based Study. Arthritis care & research, 67(2), 187-195.

National Diabetes Data Group, (1979). Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes, 28(12), 1039-1057.

Nerup, J., Platz, P., Andersen, O.O., Christy, M., Egeberg, J., Lyngsøe, J., Poulsen, J.E., Ryder, L.P., Thomsen, M., & Svejgaard, A. (1976). HLA, autoimmunity and insulin-dependent diabetes mellitus. In. The genetics of diabetes mellitus (pp. 106-114). Springer Berlin Heidelberg.

Plancher, K.D., & Petterson, S.C. (2015). Frozen Shoulder: Reported Outcomes and Results: What Should We and the Patient Expect? In Shoulder Stiffness 2015 (pp. 235-241). Springer Berlin Heidelberg.

Ranger, T.A., Wong, A.M., Cook, J.L., & Gaida, J.E. (2015). Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis. British journal of sports medicine.

Rimm, E.B., Chan, J., Stampfer, M.J., Colditz, G.A., & Willett, W.C. (1995). Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men, British Medical Journal, 310(6979), 555-559.

Sarkar, R. N., Banerjee, S., Basu, A. K., & Bandyopadhyay (2003). Rheumatological manifestations of diabetes mellitus. Journal of Ind Rheumatol Assoc,11:25-29.

Scheen, A.J. (2015). Aggressive weight reduction treatment in the management of type 2 diabetes. Diabetes, 110897(107387b).

Semenkovich, K., Brown, M.E., Svrakic, D.M., & Lustman, P.J. (2015). Depression in Type 2 Diabetes Mellitus: Prevalence, Impact, and Treatment. Drugs, 75(6), 577-587.

Shah, K.M., Clark, B.R., McGill, J.B., & Mueller, M.J. (2015). Upper extremity impairments, pain and disability in patients with diabetes mellitus. Physiotherapy, 101(2), 147-154.

Smith, L. L., Burnet, S.P., & McNeil, J. D. (2003). Musculoskeletal manifestations of diabetes mellitus. British Journal of Sports Med, 37:30-35.

Snell-Bergeon, J.K., & Maahs, D.M. (2015). Diabetes: Elevated risk of mortality in type 1 diabetes mellitus. Nature Reviews Endocrinology, 11(3), 136-138.

Sosale, B., Sosale, A.R., Mohan, A.R., Kumar, P.M., Saboo, B., Kandula, S. (2016). Cardiovascular risk factors, micro and macrovascular complications at diagnosis in patients with young onset type 2 diabetes in India: CINDI 2. Indian Journal of Endocrinology and Metabolism, 20(1), 114.

Statistics (2007). Statistics of sick leave in Norway in 2007 [http://www.nav.no]

Tao, Z., Shi, A., & Zhao J. (2015). Epidemiological Perspectives of Diabetes. Cell biochemistry and biophysics, 1-5.

WHO (2003).The burden of musculoskeletal conditions at the start of the new millennium. World Health Organ Tech Rep Ser Volume 919. Geneva, Switzerland: World Health Organization, p.1-218.

Yurdakul, F.G., Bodur, H., Çakmak, Ö.Ö., Ateş, C., Sivas, F., Eser, F., & Taşdelen, Ö.Y. (2015). On the Severity of Carpal Tunnel Syndrome: Diabetes or Metabolic Syndrome. Journal of Clinical Neurology, 11(3), 234-240.

Zehra, S.Z., Zehra, B., Nisa, F., Ali, S.Z., Zehra, S.H., & Ather, M. (2017). Measuring Organizational Commitment and Occupational Stress of Pakistani Doctors: Comparing Lahore and Karachi Public Hospitals in Gender Perspective. International Journal of Academic Research in Business and Social Sciences, 2(1) 247-255.