Genetic diversity, disease prevalence and the coronavirus pandemic

Phiri, Andrew (2020): Genetic diversity, disease prevalence and the coronavirus pandemic.

Abstract

The COVID-19 disease outbreak is the deadliest viral pandemic our generation has experienced, and much uncertainty exists over the vulnerability of different populations to the virus since a clinically-approved vaccination does not exist. Our study investigates whether evolutionary processes such as genetic diversity and cultural behaviour norms can explain the differences in COVID-19 virus infections and mortalities observed in different countries. Using a sample of 133 countries we find that populations with higher expected genetic heterozygosity and more historical exposure to infectious diseases are associated with lower COVID-19 infections and mortalities. Further investigations reveal two ‘channels’ of transmission. Firstly, a longer migratory distance from the origins of homo sapiens adversely influences expected heterozygosity, which then increases the populations susceptibility to the COVID_19 virus. Secondly, higher disease prevalence leads to higher collectivism (lower individualism) behaviour, which then reduces the populations susceptibility to COVID_19 infections. Our analysis is robust to the inclusion of additional controls and dummies. Policy implications of our findings are discussed.

• Item Type: MPRA Paper
• Language: English
• Keywords: COVID-19; Expected heterozygosity; Disease prevalence; Collectivism; Individualism; Deep roots.
• Subjects: C - Mathematical and Quantitative Methods > C3 - Multiple or Simultaneous Equation Models ; Multiple Variables > C33 - Panel Data Models ; Spatio-temporal Models; C - Mathematical and Quantitative Methods > C3 - Multiple or Simultaneous Equation Models ; Multiple Variables > C36 - Instrumental Variables (IV) Estimation; C - Mathematical and Quantitative Methods > C5 - Econometric Modeling > C52 - Model Evaluation, Validation, and Selection; I - Health, Education, and Welfare > I1 - Health > I18 - Government Policy ; Regulation ; Public Health; Z - Other Special Topics > Z1 - Cultural Economics ; Economic Sociology ; Economic Anthropology; Z - Other Special Topics > Z1 - Cultural Economics ; Economic Sociology ; Economic Anthropology > Z13 - Economic Sociology ; Economic Anthropology ; Social and Economic Stratification

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